Maternal serum adiponectin multimers in gestational diabetes

Shali Mazaki-Tovi, Roberto Romero*, Edi Vaisbuch, Offer Erez, Pooja Mittal, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Percy Pacora, Lami Yeo, Francesca Gotsch, Zhong Dong, Bo Hyun Yoon, Sonia S. Hassan, Juan Pedro Kusanovic

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objective: Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers. These oligomeric complexes circulate as low-molecular-weight (LMW) trimers, medium-molecular- weight (MMW) hexamers and high-molecular-weight (HMW) isoforms and can exert differential biological effects. The aims of this study were to determine whether there is a change in circulating adiponectin multimers in the presence of gestational diabetes mellitus (GDM), overweight/obesity or with a treatment with sulfonylurea or insulin in patients with GDM. Study design: This cross-sectional study included women with: 1) normal pregnancy (n=149); and 2) patients with GDM (n=72). Thirty-three patients with GDM were managed with diet alone. Among the others 39 diabetic patients, 17 were treated with Glyburide and 22 with insulin. The study population was further stratified by first trimester body mass index (BMI) (normal weight <25 kg/m2 vs. overweight/obese ≥25 kg/m2). Serum adiponectin multimers (total, HMW, MMW and LMW) concentrations were determined by ELISA. Results: 1) The median maternal serum of total, HMW, MMW and LMW were lower in patients with GDM than in those with normal pregnancies (P<0.001 for all comparisons); 2) patients with GDM had a lower HMW/total adiponectin ratio and a higher MMW/total and LMW/total adiponectin ratio than those with a normal pregnancy (P<0.001 for all comparisons); and 3) among GDM patients, there were no differences in the concentrations and relative distribution of adiponectin multimers between those who were managed with diet, and those who were treated with pharmacological agents. Conclusion: 1) GDM is characterized by a distinctive pattern of concentrations and relative distribution of adiponectin multimers akin to Type 2 diabetes mellitus; 2) dysregulation of adiponectin multimeres can provide a mechanistic basis for the association between adiposity and GDM.

Original languageEnglish
Pages (from-to)637-650
Number of pages14
JournalJournal of Perinatal Medicine
Issue number6
StatePublished - 2009
Externally publishedYes


FundersFunder number
National Institutes of Health
U.S. Department of Health and Human Services
National Institute of Child Health and Human DevelopmentZIAHD002400
Eunice Kennedy Shriver National Institute of Child Health and Human Development


    • Adipokines
    • Body mass index (BMI)
    • Diabetes
    • Gestational diabetes
    • High-molecular -weight (HMW) adiponectin
    • Low-molecular-weight (LMW) adiponectin
    • Medium-molecular-weight (MMW) adiponectin
    • Obesity
    • Overweight
    • Pregnancy


    Dive into the research topics of 'Maternal serum adiponectin multimers in gestational diabetes'. Together they form a unique fingerprint.

    Cite this