Maternal and Neonatal Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant Neutralization After Antenatal Messenger RNA Vaccination

Amihai Rottenstreich, Olesya Vorontsov, Or Alfi, Gila Zarbiv, Esther Oiknine-Djian, Roy Zigron, Geffen Kleinstern, Michal Mandelboim, Shay Porat, Dana G. Wolf

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the neutralization efficiency against SARS-CoV-2 Omicron variant in maternal and cord blood sera after antenatal BNT162b2 vaccination. Neutralizing antibodies against Omicron were lacking at the time of delivery after 2-dose vaccination. A third booster dose was essential in building neutralizing antibody capacity against Omicron among mothers and neonates.

Original languageEnglish
Pages (from-to)2023-2026
Number of pages4
JournalClinical Infectious Diseases
Volume75
Issue number11
DOIs
StatePublished - 30 Nov 2022
Externally publishedYes

Keywords

  • COVID-19
  • Omicron
  • pregnancy
  • SARS-CoV-2
  • vaccination

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