Maternal and fetal serum and tissue levels of ceftriaxone following preoperative prophylaxis in emergency cesarean section

Ruth Lung*, Itamar Shalit, Jehoshua Segal, Yael Arbel, Shlomo Markov, Hava Hass, Moshe Fejgin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The use of antibiotic prophylaxis in emergency cesarean section has become the standard of care. Concern over fetal exposure has been the reason that antibiotics are traditionally given post cord clamping, but this docs not allow adequate antibiotic levels in maternal blood and tissue to be achieved at the stage of incision and during surgery. We evaluated by bioassay maternal and fetal serum and placental ceftriaxone concentrations following the intravenous administration of 1.0 g of ceftriaxone upon the decision to perform cesarean section. The preoperative prophylaxis with ceftriaxone resulted in adequate protective levels in the mother and very low fetal blood levels.

Original languageEnglish
Pages (from-to)77-81
Number of pages5
JournalChemotherapy
Volume39
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • Antibiotic prophylaxis
  • Ceftriaxone
  • Cesarean section

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