Mast cells and autoimmunity

Menachem Rottem, Yoseph A. Mekori

Research output: Contribution to journalReview articlepeer-review


Mast cells (MCs) are major effector cells in allergic diseases. Recently, it has become evident that the contribution of MCs extends far beyond their accepted role in allergic disease, and that they play a more extensive role in a variety of non-allergic immune processes such as the innate immunity response. These cells have a key role in both the induction and elicitation of several autoimmune conditions. Targeting MC development, maturation or activation may be of value in future prevention and treatment of autoimmune conditions.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalAutoimmunity Reviews
Issue number1
StatePublished - Jan 2005


  • Allergy
  • Autoimmunity
  • Cytokines
  • Inflammation
  • Innate immunity
  • Mast cells
  • T cells


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