Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis

Alon Y. Hershko, Ryo Suzuki, Nicolas Charles, Damiana Alvarez-Errico, Jennifer L. Sargent, Arian Laurence, Juan Rivera

Research output: Contribution to journalArticlepeer-review

Abstract

The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (Kit W-sh/W-sh), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild-type, but not Il2 -/-, mast cells into Kit W-sh/W-sh mice dampened the inflammatory response. During the course of disease, mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation.

Original languageEnglish
Pages (from-to)562-571
Number of pages10
JournalImmunity
Volume35
Issue number4
DOIs
StatePublished - 28 Oct 2011
Externally publishedYes

Fingerprint

Dive into the research topics of 'Mast Cell Interleukin-2 Production Contributes to Suppression of Chronic Allergic Dermatitis'. Together they form a unique fingerprint.

Cite this