Mast cell and T cell communication; amplification and control of adaptive immunity

Alon Y. Hershko, Juan Rivera

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent advances in understanding the physiological role of mast cells (MCs) point to an important regulatory role for these cells in adaptive immunity. MCs express a diverse array of molecules that can promote their interaction with T cells as well as with other immune cells. New evidence demonstrates that mast cells can directly and indirectly communicate with T cells. They can control both effector and regulatory T cell responses and their activity can in turn be modulated by these interactions. Here we briefly summarize these advances and discuss some of the major challenges in understanding the communication of MCs and T cells.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalImmunology Letters
Volume128
Issue number2
DOIs
StatePublished - Feb 2010
Externally publishedYes

Keywords

  • Communication
  • Mast cells
  • Molecular interaction
  • T cells
  • T effectors
  • Tregs

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