Mast cell adenosine receptors function: A focus on the A3 adenosine receptor and inflammation

Noam Rudich, Katya Ravid, Ronit Sagi-Eisenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Adenosine is a metabolite, which has long been implicated in a variety of inflamma- tory processes. Inhaled adenosine provokes bronchoconstriction in asthmatics or chronic obstructive pulmonary disease patients, but not in non-asthmatics. This hyper responsive- ness to adenosine appears to be mediated by mast cell activation. These observations have marked the receptor that mediates the bronchoconstrictor effect of adenosine on mast cells (MCs), as an attractive drug candidate. Four subtypes (A1, A2a, A2b, and A3) of adenosine receptors have been cloned and shown to display distinct tissue distributions and functions. Animal models have firmly established the ultimate role of the A3 adeno- sine receptor (A3R) in mediating hyper responsiveness to adenosine in MCs, although the influence of the A2b adenosine receptor was confirmed as well. In contrast, studies of the A3R in humans have been controversial. In this review, we summarize data on the role of different adenosine receptors in mast cell regulation of inflammation and pathology, with a focus on the common and distinct functions of the A3R in rodent and human MCs. The relevance of mouse studies to the human is discussed.

Original languageEnglish
Article numberArticle 134
JournalFrontiers in Immunology
Volume3
Issue numberJUN
DOIs
StatePublished - 2012

Keywords

  • A3 adenosine receptor
  • Adenosine
  • Hmc-1
  • Mast cells
  • Rbl-2h3

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