TY - JOUR
T1 - Marked hypotonia in an infant of a mother with devic disease
AU - Zifman, Eyal
AU - Litmanovitz, Ita
AU - Segal, Gil
AU - Regev, Rivka
AU - Watemberg, Nathan
PY - 2010/6
Y1 - 2010/6
N2 - A full-term female neonate was born with severe hypotonia and weakness. Her mother had been treated for neuromyelitis optica (Devic disease) for 6 years. Her previous son, born 10 years earlier and before she developed the disease, also had marked hypotonia that gradually improved over several weeks. A suspicion of neonatal myasthenia gravis arose, as a search of the literature revealed the occasional detection of anti-acetylcholine receptor antibodies in patients with Devic disease. A neostigmine test was mildly positive in the baby, but anti-acetylcholine receptor antibodies were elevated. Aquaporin 4 antibodies typical of neuromyelitis optica were not detected in the infant. Because of clinical deterioration, intravenous immunoglobulin was administered with substantial improvement. Anti-acetylcholine antibodies were markedly elevated in the mother's serum, although she showed no clinical signs of myasthenia gravis. It is very likely that her previous baby also had unrecognized transient myasthenia gravis.
AB - A full-term female neonate was born with severe hypotonia and weakness. Her mother had been treated for neuromyelitis optica (Devic disease) for 6 years. Her previous son, born 10 years earlier and before she developed the disease, also had marked hypotonia that gradually improved over several weeks. A suspicion of neonatal myasthenia gravis arose, as a search of the literature revealed the occasional detection of anti-acetylcholine receptor antibodies in patients with Devic disease. A neostigmine test was mildly positive in the baby, but anti-acetylcholine receptor antibodies were elevated. Aquaporin 4 antibodies typical of neuromyelitis optica were not detected in the infant. Because of clinical deterioration, intravenous immunoglobulin was administered with substantial improvement. Anti-acetylcholine antibodies were markedly elevated in the mother's serum, although she showed no clinical signs of myasthenia gravis. It is very likely that her previous baby also had unrecognized transient myasthenia gravis.
KW - Intravenous immunoglobulin
KW - Neonatal myasthenia
KW - Neuromyelitis optica
UR - http://www.scopus.com/inward/record.url?scp=77952935262&partnerID=8YFLogxK
U2 - 10.1177/0883073809343316
DO - 10.1177/0883073809343316
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AN - SCOPUS:77952935262
SN - 0883-0738
VL - 25
SP - 746
EP - 747
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 6
ER -