TY - GEN
T1 - MAPPIS
T2 - 1st International Symposium on Computational Life Sciences, CompLife 2005
AU - Shulman-Peleg, Alexandra
AU - Shatsky, Maxim
AU - Nussinov, Ruth
AU - Wolfson, Haim J.
PY - 2005
Y1 - 2005
N2 - A protein-protein interface (PPI) is defined by a pair of regions of two interacting protein molecules that are linked by non-covalent bonds. Recognition of conserved 3D patterns of physico-chemical interactions may suggest their importance for the function as well as for the stability and formation of the protein-protein complex. It may assist in discovery of new drug leads that target these interactions. We present a novel method, MAPPIS, for multiple structural alignment of PPIs which allows recognition of a set of common physico-chemical properties and their interactions without the need to assume similarity of sequential patterns or backbone patterns. We show its application to several biological examples, such as alignment of interfaces of G proteins with their effectors and regulators, as well as previously created clusters of interfaces.
AB - A protein-protein interface (PPI) is defined by a pair of regions of two interacting protein molecules that are linked by non-covalent bonds. Recognition of conserved 3D patterns of physico-chemical interactions may suggest their importance for the function as well as for the stability and formation of the protein-protein complex. It may assist in discovery of new drug leads that target these interactions. We present a novel method, MAPPIS, for multiple structural alignment of PPIs which allows recognition of a set of common physico-chemical properties and their interactions without the need to assume similarity of sequential patterns or backbone patterns. We show its application to several biological examples, such as alignment of interfaces of G proteins with their effectors and regulators, as well as previously created clusters of interfaces.
UR - http://www.scopus.com/inward/record.url?scp=33646171091&partnerID=8YFLogxK
U2 - 10.1007/11560500_9
DO - 10.1007/11560500_9
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AN - SCOPUS:33646171091
SN - 3540291040
SN - 9783540291046
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 91
EP - 103
BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Y2 - 25 September 2005 through 27 September 2005
ER -