Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm

Keyphrases

• Binding Specificity 20%
• Catalytic Domain 20%
• Cell Proliferation 20%
• Computational Challenges 20%
• Conformational Ensemble 20%
• Conformational Space 100%
• Conformational Switching 20%
• Constitutive Activation 20%
• Control Cell 20%
• Data-driven Evolutionary Algorithm 20%
• Directly Observed 20%
• Energy Landscape 100%
• Evolutionary Algorithms 100%
• Experimental Structure 20%
• Functional Change 40%
• G12V 40%
• HEC-RAS 100%
• Human Tumors 20%
• KRAS mutation 20%
• Memetics 100%
• Molecular Biology 20%
• Molecular Dynamics 40%
• Novel Algorithm 20%
• Protein Structure Space 20%
• Ras Proteins 20%
• Search Space Reduction 20%
• Sequence mutation 20%
• Signaling Pathway 20%
• Single-point mutation 20%
• Stark Effect 20%
• Stochastic Optimization 20%
• Structure Space 20%
• Wet Laboratory 20%

Biochemistry, Genetics and Molecular Biology

• Carcinogenesis 40%
• Cell Proliferation 20%
• Conformation 100%
• Conformational Ensembles 20%
• Dynamics 40%
• Energy Landscape 100%
• Enzyme Active Site 20%
• Evolutionary Algorithms 100%
• Molecular Biology 20%
• Point Mutation 20%
• Protein Structure 20%