TY - JOUR
T1 - Mapping of the human caseis kinase II catalytic subunit genes
T2 - Two loci carrying the homologues sewquences for the α subunit
AU - Yang-feng, T. L.
AU - Zheng, K.
AU - Kopatz, I.
AU - Naiman, T.
AU - Canaani, D.
N1 - Funding Information:
This study was supported by a United States-Israel Binational Science Foundation grant and a Research Career Development Award from Israel Cancer Research Fund to D.C. The authors thank H. Han for technical assistance and C. Thacker for critical reading of this manuscript.
PY - 1991/12/25
Y1 - 1991/12/25
N2 - The human serine/threonlne protein casein kinase II (CK II) contains two distinct catalytic subunits, α and α', which are encoded by different genes. A combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization have localized the human CK II-α DNA sequence to two loci: 11p15.5-p15.4 and 20p13. In contrast, the CK ll-α' gene has been mapped to chromosome 16 by somatic cell hybrid analysis. Taken together with our previous assignment of the CK II regulatory β-subunit gene to 6p12-p21, these results indicate that although the products of these genes form a single biological complex, they are encoded on different human chromosomes. Further analysis should determine whether both loci of CK ll-α are functional, or perhaps one of the two constitutes a pseudogene.
AB - The human serine/threonlne protein casein kinase II (CK II) contains two distinct catalytic subunits, α and α', which are encoded by different genes. A combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization have localized the human CK II-α DNA sequence to two loci: 11p15.5-p15.4 and 20p13. In contrast, the CK ll-α' gene has been mapped to chromosome 16 by somatic cell hybrid analysis. Taken together with our previous assignment of the CK II regulatory β-subunit gene to 6p12-p21, these results indicate that although the products of these genes form a single biological complex, they are encoded on different human chromosomes. Further analysis should determine whether both loci of CK ll-α are functional, or perhaps one of the two constitutes a pseudogene.
UR - http://www.scopus.com/inward/record.url?scp=0026328078&partnerID=8YFLogxK
U2 - 10.1093/nar/19.25.7125
DO - 10.1093/nar/19.25.7125
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C2 - 1766873
AN - SCOPUS:0026328078
SN - 0305-1048
VL - 19
SP - 7125
EP - 7129
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - 25
ER -