Mapping of the human caseis kinase II catalytic subunit genes: Two loci carrying the homologues sewquences for the α subunit

T. L. Yang-feng*, K. Zheng, I. Kopatz, T. Naiman, D. Canaani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The human serine/threonlne protein casein kinase II (CK II) contains two distinct catalytic subunits, α and α', which are encoded by different genes. A combination of segregation analysis of rodent-human hybrid cells and chromosomal in situ hybridization have localized the human CK II-α DNA sequence to two loci: 11p15.5-p15.4 and 20p13. In contrast, the CK ll-α' gene has been mapped to chromosome 16 by somatic cell hybrid analysis. Taken together with our previous assignment of the CK II regulatory β-subunit gene to 6p12-p21, these results indicate that although the products of these genes form a single biological complex, they are encoded on different human chromosomes. Further analysis should determine whether both loci of CK ll-α are functional, or perhaps one of the two constitutes a pseudogene.

Original languageEnglish
Pages (from-to)7125-7129
Number of pages5
JournalNucleic Acids Research
Volume19
Issue number25
DOIs
StatePublished - 25 Dec 1991

Funding

FundersFunder number
Israel Cancer Research Fund
United States-Israel Binational Science Foundation

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