Abstract
The human mitochondrial Hsp70, mortalin, is dually distributed between the mitochondria and the cytosol. Inside the mitochondrial matrix, it plays crucial roles in mediating the import of nuclear-encoded precursor proteins and in the folding of newly imported and stress-denatured client-proteins. Outside the mitochondria it interacts with a wide-variety of proteins, which are mainly involved in cell-cycle regulation and the immune response. Similar to mortalin, its partner Tid1, the human mitochondrial DnaJ homologue, is also dually distributed and is found associated with numerous cytosolic proteins. The structural and functional significance of a selected number of interactions is discussed.
Original language | English |
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Title of host publication | Mortalin Biology |
Subtitle of host publication | Life, Stress and Death |
Publisher | Springer Netherlands |
Pages | 225-244 |
Number of pages | 20 |
Volume | 9789400730274 |
ISBN (Electronic) | 9789400730274 |
ISBN (Print) | 9400730268, 9789400730267 |
DOIs | |
State | Published - 1 Apr 2012 |
Keywords
- Chaperone
- Folding
- Import
- Mitochondria
- MtHsp70
- Protein-protein interactions