Many faces of mortalin and Tid1

Ohad Iosefson, Abdussalam Azem*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The human mitochondrial Hsp70, mortalin, is dually distributed between the mitochondria and the cytosol. Inside the mitochondrial matrix, it plays crucial roles in mediating the import of nuclear-encoded precursor proteins and in the folding of newly imported and stress-denatured client-proteins. Outside the mitochondria it interacts with a wide-variety of proteins, which are mainly involved in cell-cycle regulation and the immune response. Similar to mortalin, its partner Tid1, the human mitochondrial DnaJ homologue, is also dually distributed and is found associated with numerous cytosolic proteins. The structural and functional significance of a selected number of interactions is discussed.

Original languageEnglish
Title of host publicationMortalin Biology
Subtitle of host publicationLife, Stress and Death
PublisherSpringer Netherlands
Number of pages20
ISBN (Electronic)9789400730274
ISBN (Print)9400730268, 9789400730267
StatePublished - 1 Apr 2012


  • Chaperone
  • Folding
  • Import
  • Mitochondria
  • MtHsp70
  • Protein-protein interactions


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