Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi

Zvi Bar-Shavit; Itzhak Ofek; Rachel Goldman; David Mirelman; Nathan Sharon

doi:10.1016/0006-291X(77)91276-1

Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi

Zvi Bar-Shavit^*, Itzhak Ofek, Rachel Goldman, David Mirelman, Nathan Sharon

^*Corresponding author for this work

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Abstract

The attachment of Escherichia coli and Salmonella typhi to mouse peritoneal macrophages was inhibited by D-mannose, methyl α-D-mannopyranoside and yeast mannan, but not by any other sugar tested. D-Mannose and its derivatives also inhibited the attachment of E. coli to human polymorphonuclear leucocytes. Mannan inhibited phagocytosis when preincubated with E. coli, but not when preincubated with leucocytes. Attachment of opsonized bacteria to leucocytes was not inhibited by D-mannose or methyl α-D-mannopyranoside nor by any other sugar tested. Our results suggest that the surface of phagocytes, like that of epithelial cells, contains D-mannose residues which serve for the attachment of certain Gram negative bacteria.

Original language	English
Pages (from-to)	455-460
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	78
Issue number	1
DOIs	https://doi.org/10.1016/0006-291X(77)91276-1
State	Published - 9 Sep 1977
Externally published	Yes

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abstract = "The attachment of Escherichia coli and Salmonella typhi to mouse peritoneal macrophages was inhibited by D-mannose, methyl α-D-mannopyranoside and yeast mannan, but not by any other sugar tested. D-Mannose and its derivatives also inhibited the attachment of E. coli to human polymorphonuclear leucocytes. Mannan inhibited phagocytosis when preincubated with E. coli, but not when preincubated with leucocytes. Attachment of opsonized bacteria to leucocytes was not inhibited by D-mannose or methyl α-D-mannopyranoside nor by any other sugar tested. Our results suggest that the surface of phagocytes, like that of epithelial cells, contains D-mannose residues which serve for the attachment of certain Gram negative bacteria.",

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AU - Bar-Shavit, Zvi

AU - Ofek, Itzhak

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AU - Mirelman, David

AU - Sharon, Nathan

PY - 1977/9/9

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N2 - The attachment of Escherichia coli and Salmonella typhi to mouse peritoneal macrophages was inhibited by D-mannose, methyl α-D-mannopyranoside and yeast mannan, but not by any other sugar tested. D-Mannose and its derivatives also inhibited the attachment of E. coli to human polymorphonuclear leucocytes. Mannan inhibited phagocytosis when preincubated with E. coli, but not when preincubated with leucocytes. Attachment of opsonized bacteria to leucocytes was not inhibited by D-mannose or methyl α-D-mannopyranoside nor by any other sugar tested. Our results suggest that the surface of phagocytes, like that of epithelial cells, contains D-mannose residues which serve for the attachment of certain Gram negative bacteria.

AB - The attachment of Escherichia coli and Salmonella typhi to mouse peritoneal macrophages was inhibited by D-mannose, methyl α-D-mannopyranoside and yeast mannan, but not by any other sugar tested. D-Mannose and its derivatives also inhibited the attachment of E. coli to human polymorphonuclear leucocytes. Mannan inhibited phagocytosis when preincubated with E. coli, but not when preincubated with leucocytes. Attachment of opsonized bacteria to leucocytes was not inhibited by D-mannose or methyl α-D-mannopyranoside nor by any other sugar tested. Our results suggest that the surface of phagocytes, like that of epithelial cells, contains D-mannose residues which serve for the attachment of certain Gram negative bacteria.

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Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi

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