TY - JOUR
T1 - Manipulating single enzymes by an external harmonic force
AU - Lomholt, Michael A.
AU - Urbakh, Michael
AU - Metzler, Ralf
AU - Klafter, Joseph
PY - 2007/4/19
Y1 - 2007/4/19
N2 - We study a Michaelis-Menten reaction for a single two-state enzyme molecule, whose transition rates between the two conformations are modulated by an harmonically oscillating external force. In particular, we obtain a range of optimal driving frequencies for changing the conformation of the enzyme, thereby controlling the enzymatic activity (i.e., product formation). This analysis demonstrates that it is, in principle, possible to obtain information about particular rates within the kinetic scheme.
AB - We study a Michaelis-Menten reaction for a single two-state enzyme molecule, whose transition rates between the two conformations are modulated by an harmonically oscillating external force. In particular, we obtain a range of optimal driving frequencies for changing the conformation of the enzyme, thereby controlling the enzymatic activity (i.e., product formation). This analysis demonstrates that it is, in principle, possible to obtain information about particular rates within the kinetic scheme.
UR - http://www.scopus.com/inward/record.url?scp=34247341250&partnerID=8YFLogxK
U2 - 10.1103/PhysRevLett.98.168302
DO - 10.1103/PhysRevLett.98.168302
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C2 - 17501470
AN - SCOPUS:34247341250
SN - 0031-9007
VL - 98
JO - Physical Review Letters
JF - Physical Review Letters
IS - 16
M1 - 168302
ER -