Manifestations of Herpes Virus Infections in the Nervous System

Israel Steiner*, Felix Benninger

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


The 3 neurotropic human herpes viruses, herpes simplex virus (HSV) type 1 and 2, and varicella-zoster virus (VZV) are capable of establishment of latent viral infection in trigeminal and dorsal root ganglia. HSV-1, and more rarely HSV-2, carries the potential to cause meningoencephalitis, with devastating clinical consequences. Immediate diagnosis, based on clinical presentation, MRI imaging, and molecular diagnosis by polymerase chain reaction, and initiation of therapy are mandatory to reduce mortality and neurologic permanent sequelae. VZV is associated with postprimary infection and reactivation disorders that may affect anywhere in the neuraxis. Early diagnosis and therapy are required.

Original languageEnglish
Pages (from-to)725-738
Number of pages14
JournalNeurologic Clinics
Issue number4
StatePublished - Nov 2018


  • Encephalitis
  • Herpes simplex virus
  • Meningoencephalitis
  • Postinfection
  • Reactivation infection
  • Varicella-zoster virus


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