Managing hypertension in the elderly in light of the changes during aging

Talma Rosenthal*, Naomi Nussinovitch

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review


The natural rise in systolic blood pressure with age is often complicated by other co-morbidities. Pharmacokinetics and pharmacodynamics of antihypertensive drugs are altered during aging, resulting in decrease in absorption and function of the kidney and liver, as well as interactions and adverse reactions of antihypertensives with the often large number of medications taken by the elderly. The problem of compliance in the elderly that may be disrupted by depression, loss of memory, vascular dementia and other conditions that compromise cognition is also of concern. Despite the many issues facing healthcare providers in managing hypertension in the elderly, the benefits are extensively documented and warrant overcoming therapeutic inertia, especially in view of current access to well documented therapeutic options.

Original languageEnglish
Pages (from-to)186-194
Number of pages9
JournalBlood Pressure
Issue number4
StatePublished - 2008
Externally publishedYes


  • Aging
  • Altered metabolism
  • Polypharmacy


Dive into the research topics of 'Managing hypertension in the elderly in light of the changes during aging'. Together they form a unique fingerprint.

Cite this