TY - JOUR
T1 - Management of bisphosphonate-associated osteonecrosis
T2 - Pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series
AU - Epstein, Matthew S.
AU - Wicknick, Fredrick W.
AU - Epstein, Joel B.
AU - Berenson, James R.
AU - Gorsky, Meir
PY - 2010/11
Y1 - 2010/11
N2 - Background: Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON). Methods: Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months. Results: A 74% decrease in area of bony exposure and symptom control was achieved in these cases. Discussion: Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.
AB - Background: Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON). Methods: Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months. Results: A 74% decrease in area of bony exposure and symptom control was achieved in these cases. Discussion: Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.
UR - http://www.scopus.com/inward/record.url?scp=77958082644&partnerID=8YFLogxK
U2 - 10.1016/j.tripleo.2010.05.067
DO - 10.1016/j.tripleo.2010.05.067
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AN - SCOPUS:77958082644
SN - 1079-2104
VL - 110
SP - 593
EP - 596
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 5
ER -