Management of bisphosphonate-associated osteonecrosis: Pentoxifylline and tocopherol in addition to antimicrobial therapy. An initial case series

Matthew S. Epstein, Fredrick W. Wicknick, Joel B. Epstein, James R. Berenson, Meir Gorsky

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON). Methods: Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months. Results: A 74% decrease in area of bony exposure and symptom control was achieved in these cases. Discussion: Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume110
Issue number5
DOIs
StatePublished - Nov 2010

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