TY - JOUR
T1 - Malignant bronchial carcinoid tumor metastatic to the pituitary in a thyroid carcinoma patient
T2 - Successful treatment with surgery, radiotherapy and somatostatin analog
AU - Shimon, Ilan
AU - Hadani, Moshe
AU - Nass, Dvora
AU - Zwas, S. Tzila
PY - 2004
Y1 - 2004
N2 - A carcinoid pituitary metastasis is very rare, and is reported scarcely in a few patients. We describe an unusual case of metastatic atypical bronchial carcinoid to the anterior pituitary gland in a 47-year-old male who presented with bitemporal hemianopsia and hypopituitarism. His primary bronchial carcinoid was resected two years previously. Foci of metastatic papillary thyroid carcinoma were also identified in the lung resected for the bronchial carcinoid. He thereby underwent total thyroidectomy followed by radioiodine ablative treatment. Transsphenoidal partial removal of the suprasellar mass was performed, and atypical carcinoid metastasis was identified. He received conventional fractionated sellar radiotherapy, which was supplemented with octreotide (Sandostatin LAR) injections following a positive pituitary uptake on octreotide scan. This treatment suppressed his elevated 5-HIAA urinary excretion to a normal level. His vision has returned to normal and the pituitary mass diminished in size.
AB - A carcinoid pituitary metastasis is very rare, and is reported scarcely in a few patients. We describe an unusual case of metastatic atypical bronchial carcinoid to the anterior pituitary gland in a 47-year-old male who presented with bitemporal hemianopsia and hypopituitarism. His primary bronchial carcinoid was resected two years previously. Foci of metastatic papillary thyroid carcinoma were also identified in the lung resected for the bronchial carcinoid. He thereby underwent total thyroidectomy followed by radioiodine ablative treatment. Transsphenoidal partial removal of the suprasellar mass was performed, and atypical carcinoid metastasis was identified. He received conventional fractionated sellar radiotherapy, which was supplemented with octreotide (Sandostatin LAR) injections following a positive pituitary uptake on octreotide scan. This treatment suppressed his elevated 5-HIAA urinary excretion to a normal level. His vision has returned to normal and the pituitary mass diminished in size.
KW - Carcinoid
KW - Octreotide
KW - Papillary thyroid carcinoma
KW - Pituitary metastasis
UR - http://www.scopus.com/inward/record.url?scp=5644238516&partnerID=8YFLogxK
U2 - 10.1023/B:PITU.0000044627.63261.b4
DO - 10.1023/B:PITU.0000044627.63261.b4
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AN - SCOPUS:5644238516
VL - 7
SP - 51
EP - 57
JO - Pituitary
JF - Pituitary
SN - 1386-341X
IS - 1
ER -