Malignancy of the bone: Primary tumors, lymphoma, and skeletal metastases

Einat Even-Sapir*, Gideon Flusser, Arye Blachar

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Most malignant skeletal lesions initiate intramedullary. As the intramedullary malignant deposit enlarges, the surrounding bone undergoes osteoclastic and osteoblastic activity. Tumor cells may destroy bone directly or produce mediators that stimulate reabsorption by osteoclasts.1Based on the balance between the two processes, the radiographic appearance of a malignant skeletal lesion may be lytic, blastic, or mixed.2Detection of malignant skeletal involvement is based on either direct visualization of tumor cells or of the secondary reaction of the bone to the present malignant cells.

Original languageEnglish
Title of host publicationHybrid PET/CT and SPECT/CT Imaging
Subtitle of host publicationA Teaching File
PublisherSpringer New York
Number of pages37
ISBN (Print)9780387928197
StatePublished - 2010


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