TY - CHAP
T1 - Malignancy of the bone
T2 - Primary tumors, lymphoma, and skeletal metastases
AU - Even-Sapir, Einat
AU - Flusser, Gideon
AU - Blachar, Arye
PY - 2010
Y1 - 2010
N2 - Most malignant skeletal lesions initiate intramedullary. As the intramedullary malignant deposit enlarges, the surrounding bone undergoes osteoclastic and osteoblastic activity. Tumor cells may destroy bone directly or produce mediators that stimulate reabsorption by osteoclasts.1Based on the balance between the two processes, the radiographic appearance of a malignant skeletal lesion may be lytic, blastic, or mixed.2Detection of malignant skeletal involvement is based on either direct visualization of tumor cells or of the secondary reaction of the bone to the present malignant cells.
AB - Most malignant skeletal lesions initiate intramedullary. As the intramedullary malignant deposit enlarges, the surrounding bone undergoes osteoclastic and osteoblastic activity. Tumor cells may destroy bone directly or produce mediators that stimulate reabsorption by osteoclasts.1Based on the balance between the two processes, the radiographic appearance of a malignant skeletal lesion may be lytic, blastic, or mixed.2Detection of malignant skeletal involvement is based on either direct visualization of tumor cells or of the secondary reaction of the bone to the present malignant cells.
UR - http://www.scopus.com/inward/record.url?scp=84892346537&partnerID=8YFLogxK
U2 - 10.1007/978-0-387-92820-3_16
DO - 10.1007/978-0-387-92820-3_16
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AN - SCOPUS:84892346537
SN - 9780387928197
SP - 583
EP - 619
BT - Hybrid PET/CT and SPECT/CT Imaging
PB - Springer New York
ER -