Malaria drugs: Clues from malaria resistance genetics

Research output: Contribution to journalReview articlepeer-review

Abstract

New treatments for malaria are desperately needed. Malaria drug design can be assisted by knowledge on protective host genotypes. Individuals immune to severe malaria, being only mildly affected by the parasite infection, may carry alleles that provide protection from severe disease, which may provide clues for drug discovery. Lessons about protective genotypes have improved our understanding on the transmission and pathogenicity of the human immunodeficiency virus and have led to novel drug design. Similarly, clues from malaria protective genes may help in the design of new malaria therapies.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalDrug Development Research
Volume71
Issue number1
DOIs
StatePublished - Feb 2010

Keywords

  • Duffy antigen
  • Glucose-6-phosphate dehydrogenase
  • Glycolysis inhibitors
  • Malaria resistance
  • Plasmodium falciparum
  • Plasmodium vivax
  • Sickle cell hemoglobin

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