TY - JOUR
T1 - Making β cells from adult tissues
AU - Efrat, Shimon
AU - Russ, Holger A.
N1 - Funding Information:
Work in the laboratory of S.E. is supported by the Israel Science Foundation and the Juvenile Diabetes Research Foundation.
PY - 2012/6
Y1 - 2012/6
N2 - β-Cell replacement represents an attractive prospect for diabetes therapy. Although much hope has been placed on derivation of insulin-producing cells from human pluripotent stem cells, this approach continues to face considerable challenges. Cells from adult human tissues, with both stem/progenitor and mature phenotypes, offer a possible alternative. This review summarizes recent progress in two major strategies based on this cell source, . ex vivo expansion of human islet β cells and conversion of non-β cells into insulin-producing cells by nuclear reprogramming, and examines the obstacles that remain to be overcome for bringing these strategies closer to clinical application in diabetes therapy.
AB - β-Cell replacement represents an attractive prospect for diabetes therapy. Although much hope has been placed on derivation of insulin-producing cells from human pluripotent stem cells, this approach continues to face considerable challenges. Cells from adult human tissues, with both stem/progenitor and mature phenotypes, offer a possible alternative. This review summarizes recent progress in two major strategies based on this cell source, . ex vivo expansion of human islet β cells and conversion of non-β cells into insulin-producing cells by nuclear reprogramming, and examines the obstacles that remain to be overcome for bringing these strategies closer to clinical application in diabetes therapy.
UR - http://www.scopus.com/inward/record.url?scp=84861712541&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2012.03.005
DO - 10.1016/j.tem.2012.03.005
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AN - SCOPUS:84861712541
VL - 23
SP - 278
EP - 285
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
SN - 1043-2760
IS - 6
ER -
