Major depressive disorder: Treatment and future perspective

Roman Gersner, Oded Rosenberg*, Pinhas N. Dannon

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Major depressive disorder is a mood disorder characterized by both severe affective and neurovegetative symptoms together. It is a common disorder seen in a quarter of consecutively admitted depressed patients and is often associated with severe symptomatology, increased suicide risk, poor acute response to antidepressants and poor acute and long-term treatment outcome. The question of the optimal duration of pharmacotherapy in order to prevent relapse and improve the long-term (i.e., 5-year) outcome is a focus of current investigation. This article will review currently recommended treatment strategies for the acute, continuation and maintenance phases of therapy. In particular, it will address the role of newer-generation antidepressants, the use of mood stabilizers and indications for electroconvulsive therapy. Other possible treatment strategies such as transcranial magnetic stimulation, vagus nerve stimulation, deep brain stimulation and glucocorticoid receptor antagonists will be discussed.

Original languageEnglish
Pages (from-to)269-278
Number of pages10
JournalClinical Practice
Issue number3
StatePublished - May 2012


Dive into the research topics of 'Major depressive disorder: Treatment and future perspective'. Together they form a unique fingerprint.

Cite this