@article{65ab48c0b99e43ad83bbe5f8a013a3bc,
title = "Maintaining integrity",
abstract = "Research on genome stability and integrity now extends far beyond the biochemistry of DNA repair to encompass signal transduction pathways that span numerous aspects of cellular life. Derailed genomic integrity pathways can result in debilitating genetic disorders, premature ageing, predisposition to cancer and degenerative conditions. Current progress in this rapidly expanding field was the subject of an EMBO workshop, Maintenance of Genomic Integrity, that took place in June 2004 in Galway, Ireland.",
author = "Yosef Shiloh and Lehmann, {Alan R.}",
note = "Funding Information: The meeting demonstrated the growing number of technologies and the different areas of cell biology that the genome stability field now involves. Particularly impressive is the power of real-time imaging in live cells, which allows the dissection of the fast and complex DNA damage response. It is no surprise — considering that a single, unrepaired DNA lesion, such as a DSB, can put the life of the cell at risk — that the cellular response to DNA damage is global, vigorous and uncompromising. Genome stability, crucial to our health and vitality, is expected to remain at the forefront of biomedical research for the foreseeable future. A note from the authors: we apologize to the many participants in this wide-ranging meeting whose excellent contributions could not be mentioned here owing to space limitations. We also acknowledge the support of the Science Foundation of Ireland and the University of Galway.",
year = "2004",
month = oct,
doi = "10.1038/ncb1004-923",
language = "אנגלית",
volume = "6",
pages = "923--928",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "Nature Publishing Group",
number = "10",
}
