Magnetothermal Multiplexing for Selective Remote Control of Cell Signaling

Junsang Moon, Michael G. Christiansen, Siyuan Rao, Colin Marcus, David C. Bono, Dekel Rosenfeld, Danijela Gregurec, Georgios Varnavides, Po Han Chiang, Seongjun Park, Polina Anikeeva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

Magnetic nanoparticles have garnered sustained research interest for their promise in biomedical applications including diagnostic imaging, triggered drug release, cancer hyperthermia, and neural stimulation. Many of these applications make use of heat dissipation by ferrite nanoparticles under alternating magnetic fields, with these fields acting as an externally administered stimulus that is either present or absent, toggling heat dissipation on and off. Here, an extension of this concept, magnetothermal multiplexing is demonstrated, in which exposure to alternating magnetic fields of differing amplitude and frequency can result in selective and independent heating of magnetic nanoparticle ensembles. The differing magnetic coercivity of these particles, empirically characterized by a custom high amplitude alternating current magnetometer, informs the systematic selection of a multiplexed material system. This work culminates in a demonstration of magnetothermal multiplexing for selective remote control of cellular signaling in vitro.

Original languageEnglish
Article number2000577
JournalAdvanced Functional Materials
Volume30
Issue number36
DOIs
StatePublished - 1 Sep 2020
Externally publishedYes

Funding

FundersFunder number
National Science Foundation1K99MH120279‐01
National Institutes of HealthDMR‐14‐19807, 1R01MH111872
Defense Advanced Research Projects AgencyHR0011‐15‐C‐0155
Samsung1K99MH120279-01

    Keywords

    • AC magnetometer
    • cellular signaling control
    • magnetic nanoparticles
    • multiplexed magnetothermal control
    • selective nanoparticle heating

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