Magnetically amplified DNA assays (MADA): Sensing of viral DNA and single-base mis-matches by using nucleic acid modified magnetic particles

Fernando Patolsky, Yossi Weizmann, Eugenii Katz, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Taking DNA analysis for a spin: Amplified detection of viral DNA and single-base mutations in nucleic acids is accomplished by the thermally cycled incorporation of biotin labels into DNA replica associated with magnetic particles, by the electrocatalyzed biochemiluminescence transduction of the DNA recognition events, and by the rotation of the magnetic particles on electrode surfaces (see schematic representation).

Original languageEnglish
Pages (from-to)2372-2376
Number of pages5
JournalAngewandte Chemie - International Edition
Volume42
Issue number21
DOIs
StatePublished - 30 May 2003
Externally publishedYes

Keywords

  • Biosensors
  • Chemiluminescence
  • DNA
  • Magnetic particles

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