Magnetic resonance enterography in pregnant women with Crohn's disease: Case series and literature review

Myriam D. Stern, Uri Kopylov*, Shomron Ben-Horin, Sarah Apter, Marianne M. Amitai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Evaluation of pregnant women with known or suspected Crohn's disease (CD) remains a challenge. Magnetic Resonance Enterography (MRE) is a promising diagnostic tool in these patients; however, the clinical data on MRE utilization in pregnancy is scarce. The aim of the study was to describe the experience with MRE in pregnant CD patients in a tertiary referral center. Methods: We retrospectively reviewed MRE studies performed in pregnant women with known or suspected CD that were performed between January 2007 and November 2012. Imaging findings, clinical management and outcome were extracted from patient's file and electronic records. Image quality was evaluated. Results: Ten studies of 9 patients were included. MRE protocol was modified to maximize maternal and fetal safety, and intravenous gadolinium was not used. In 7 patients, CD diagnosis was previously established; six were admitted with clinical symptoms consistent with CD exacerbation, and an additional patient with a recurrent groin abscess without apparent luminal symptoms. In all seven patients, imaging features consistent with active CD were detected; new penetrating complications were detected in 4 patients. Two patients underwent MRE for suspected CD which was not comforted by study results. The clinical management was significantly impacted by MRE results in all positive cases. The image quality of the fast MRE sequences obtained without gadolinium was satisfactory and allowed meaningful interpretation. Conclusion: MRE with an adapted protocol for pregnancy is a reliable imaging modality to manage in pregnant women with known or suspected CD.

Original languageEnglish
Article number146
JournalBMC Gastroenterology
Volume14
Issue number1
DOIs
StatePublished - 16 Aug 2014
Externally publishedYes

Keywords

  • Crohn's disease
  • MRI
  • Magnetic resonance enterography
  • Pregnancy

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