Magnetic nanoparticles-based acoustical detection and hyperthermic treatment of cancer, in vitro and in vivo studies

Asaf Shoval, Michal Tepper, Jenny Tikochkiy, Leah Ben Gur, Gil Markovich, Yona Keisari, Israel Gannot*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This paper describes a minimally invasive method for detection and growth inhibition of tumors that utilizes the unique properties of super paramagnetic nanoparticles. To demonstrate the feasibility of this method, dimercaptosuccinic acid-coated magnetite nanoparticles were successfully fabricated and used. Those nanoparticles were simultaneously used for magnetoacoustic detection of tumors and for specific hyperthermia treatment in C57BL/J mice injected with Lewis lung carcinoma cells. The in vivo acoustic signal attributed to the nanoparticles was 4.4 dB, while the single session hyperthermia treatment caused a reduction of 50% in tumor growing rate. In addition, a thermography-based method was applied to monitor the efficacy of the hyperthermia treatment. The presented method has the potential to revolutionize current cancer treatment by enabling diagnosis and treatment under real-time feedback in one session.

Original languageEnglish
Article number036007
JournalJournal of Nanophotonics
Volume10
Issue number3
DOIs
StatePublished - 1 Jul 2016

Keywords

  • cancer
  • hyperthermia therapy
  • magnetic nanoparticles
  • thermography

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