Magnesium-deficient diet aggravates anaphylactic shock and promotes cardiac myolysis in guinea pigs.

Y. Ashkenazy, S. Moshonov, G. Fischer, D. Feigel, A. Caspi, F. Kusniec, B. A. Sela, U. Zor

Research output: Contribution to journalArticlepeer-review


Actively sensitized guinea pigs were rendered Mg(2+)-deficient for 2-3 weeks and then subjected to immune stress. No differences could be seen between treated and control groups prior to immune challenge. 1-2 h after antigen challenge, 95% of the Mg(2+)-deficient animals were observed to be anaphylactic, i.e. apathetic, dyspneic, and they had a rapid pulse rate. Only 4% of the control animals showed signs of anaphylaxis. Serum magnesium concentration, [Mg2+], fell from 1.32 +/- 0.07 mM in control guinea pigs to 0.56 +/- 0.04 mM in those fed an Mg(2+)-deficient diet. Cardiomyolysis (CM) developed in 19% of the anaphylactic animals and in 3% of the controls. We conclude that Mg(2+)-deficient animals continue to function, provided conditions are normal, but they are unable to withstand stress. The heart, however, appears to be better equipped to defend itself against Mg2+ deficiency and low serum [Mg2+], a supposition supported by the fact that heart [Mg2+] is not significantly reduced in hypomagnesemic guinea pigs (0.864 +/- 0.021 microgram/mg dry weight in control, and 0.834 +/- 0.062 microgram/mg dry weight in magnesium-deficient animals). The data indicate that hypomagnesemia heightens the intensity of the immune response, thereby exacerbating both anaphylactic shock (AS) and CM. A normal serum [Mg2+] would thus seem essential for protection against immune stress.

Original languageEnglish
Pages (from-to)283-288
Number of pages6
JournalMagnesium and trace elements
Issue number5
StatePublished - 1990
Externally publishedYes


Dive into the research topics of 'Magnesium-deficient diet aggravates anaphylactic shock and promotes cardiac myolysis in guinea pigs.'. Together they form a unique fingerprint.

Cite this