Macrophages and regeneration: Lessons from the heart

Jonathan Leor*, Dahlia Palevski, Uri Amit, Tal Konfino

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

One of the most ambitious goals in modern cardiology is to regenerate the injured myocardium. The human myocardium has poor regenerative power. Thus, significant myocardial injury results in irreversible damage, scar formation, remodeling, and dysfunction. The search for therapies that will improve myocardial regeneration needs a better understanding of the mechanisms of repair and regeneration. While the role of macrophages in inflammation, scar formation, and fibrosis are well defined, their role in myocardial regeneration is less clear. Recent reports have suggested that cardiac macrophages regulate myocardial regeneration in neonatal mice. The present review aims to describe the latest discoveries about the possible role of macrophages in myocardial regeneration. We discuss the promises and difficulties to translate the latest findings into new therapies.

Original languageEnglish
Pages (from-to)26-33
Number of pages8
JournalSeminars in Cell and Developmental Biology
Volume58
DOIs
StatePublished - 1 Oct 2016

Keywords

  • Heart
  • Inflammation
  • Macrophage
  • Monocyte
  • Myocardial infarction
  • Regeneration

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