TY - JOUR
T1 - Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex
AU - Gore, Yael
AU - Starlets, Diana
AU - Maharshak, Nitsan
AU - Becker-Herman, Shirly
AU - Kaneyuki, Utako
AU - Leng, Lin
AU - Bucala, Richard
AU - Shachar, Idit
PY - 2008/2/1
Y1 - 2008/2/1
N2 - Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-κB activation, proliferation, and survival in a CD74-and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population.
AB - Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-κB activation, proliferation, and survival in a CD74-and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population.
UR - http://www.scopus.com/inward/record.url?scp=40949087882&partnerID=8YFLogxK
U2 - 10.1074/jbc.M703265200
DO - 10.1074/jbc.M703265200
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C2 - 18056708
AN - SCOPUS:40949087882
SN - 0021-9258
VL - 283
SP - 2784
EP - 2792
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 5
ER -
