Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex

Yael Gore, Diana Starlets, Nitsan Maharshak, Shirly Becker-Herman, Utako Kaneyuki, Lin Leng, Richard Bucala, Idit Shachar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

206 Scopus citations

Abstract

Macrophage migration inhibitory factor (MIF) is an upstream activator of innate immunity that regulates subsequent adaptive responses. It was previously shown that in macrophages, MIF binds to a complex of CD74 and CD44, resulting in initiation of a signaling pathway. In the current study, we investigated the role of MIF in B cell survival. We show that in B lymphocytes, MIF initiates a signaling cascade that involves Syk and Akt, leading to NF-κB activation, proliferation, and survival in a CD74-and CD44-dependent manner. Thus, MIF regulates the adaptive immune response by maintaining the mature B cell population.

Original languageEnglish
Pages (from-to)2784-2792
Number of pages9
JournalJournal of Biological Chemistry
Volume283
Issue number5
DOIs
StatePublished - 1 Feb 2008
Externally publishedYes

Funding

FundersFunder number
National Institute of Allergy and Infectious DiseasesR01AI042310

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