@article{adce3f84cbbc46dd8e9445e6239a39ef,
title = "M protein mediated adhesion of M type 24 Streptococcus pyogenes stimulates release of interleukin-6 by HEp-2 tissue culture cells",
abstract = "We investigated the contributions of lipoteichoic acid and M protein to reversible and irreversible adhesion of group A streptococci and the effects of such adhesion on release of interleukin-6. Streptococci in which lipoteichoic acid was masked by the hyaluronate capsule were readily washed from HEp-2 cells, indicating no attachment. Unencapsulated, M-negative streptococci in which lipoteichoic acid was exposed were removed more slowly, indicating loose attachment. Only unencapsulated streptococci that expressed both lipoteichoic acid and M protein remained stably adherent to HEp-2 cells throughout multiple washes. Streptococci expressing both M protein and lipoteichoic acid induced release of interleukin-6 from HEp-2 cells, whereas an isogenic, M-negative mutant failed to induce release of interleukin-6. These data suggest that lipoteichoic acid mediates reversible adhesion and that M protein is required for irreversible adhesion and for inducing release of interleukin-6 from HEp-2 cells.",
keywords = "Cytokine, M protein, Streptococcus pyogenes",
author = "Courtney, {Harry S.} and Itzhak Ofek and Hasty, {David L.}",
note = "Funding Information: We thank Yi Li for excellent technical assistance. This study was supported by research funds form the U.S. Department of Veterans Affairs.",
year = "1997",
month = jun,
day = "1",
doi = "10.1016/S0378-1097(97)00139-0",
language = "אנגלית",
volume = "151",
pages = "65--70",
journal = "FEMS Microbiology Letters",
issn = "0378-1097",
publisher = "Oxford University Press",
number = "1",
}