Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

Avi Khafif*, Shlomo Schneebaum, Dan M. Fliss, Hedva Lerman, U. Metser, Rami Ben-Yosef, Ziv Gil, Leonor Reider-Trejo, Livshitz Genadi, Einat Even-Sapir

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC). Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. AK patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen. Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%). Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.

Original languageEnglish
Pages (from-to)874-879
Number of pages6
JournalHead and Neck
Volume28
Issue number10
DOIs
StatePublished - Oct 2006

Keywords

  • Hybrid SPECT/CT
  • Lymphoscintigraphy
  • Oral cavity SCC

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