Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

Avi Khafif; Shlomo Schneebaum; Dan M. Fliss; Hedva Lerman; U. Metser; Rami Ben-Yosef; Ziv Gil; Leonor Reider-Trejo; Livshitz Genadi; Einat Even-Sapir

doi:10.1002/hed.20434

Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

Avi Khafif^*, Shlomo Schneebaum, Dan M. Fliss, Hedva Lerman, U. Metser, Rami Ben-Yosef, Ziv Gil, Leonor Reider-Trejo, Livshitz Genadi, Einat Even-Sapir

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC). Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. AK patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen. Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%). Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.

Original language	English
Pages (from-to)	874-879
Number of pages	6
Journal	Head and Neck
Volume	28
Issue number	10
DOIs	https://doi.org/10.1002/hed.20434
State	Published - Oct 2006

Keywords

Hybrid SPECT/CT
Lymphoscintigraphy
Oral cavity SCC

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10.1002/hed.20434

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title = "Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma",

abstract = "Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC). Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. AK patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen. Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%). Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.",

keywords = "Hybrid SPECT/CT, Lymphoscintigraphy, Oral cavity SCC",

author = "Avi Khafif and Shlomo Schneebaum and Fliss, {Dan M.} and Hedva Lerman and U. Metser and Rami Ben-Yosef and Ziv Gil and Leonor Reider-Trejo and Livshitz Genadi and Einat Even-Sapir",

year = "2006",

month = oct,

doi = "10.1002/hed.20434",

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AU - Khafif, Avi

AU - Schneebaum, Shlomo

AU - Fliss, Dan M.

AU - Lerman, Hedva

AU - Metser, U.

AU - Ben-Yosef, Rami

AU - Gil, Ziv

AU - Reider-Trejo, Leonor

AU - Genadi, Livshitz

AU - Even-Sapir, Einat

PY - 2006/10

Y1 - 2006/10

N2 - Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC). Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. AK patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen. Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%). Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.

AB - Background. We assessed the added clinical value of fused single photon emission computed tomography (SPECT) and low-dose CT images compared with planar images for sentinel node (SN) mapping in patients with oral cavity squamous cell carcinoma (SCC). Methods. Twenty consecutive patients with newly diagnosed biopsy-proven SCC of the oral cavity were enrolled. Scintigraphy was performed using a hybrid gamma-camera/low-dose CT system. Planar images and fused SPECT/CT images were interpreted separately. AK patients underwent a sentinel node biopsy (SNB) followed by a neck dissection. All SNs underwent meticulous pathologic examination and immunohistochemistry staining (cytokeratin complex) in addition to routine pathologic examinations of the neck dissection specimen. Results. The sensitivity for the detection of nodal metastases was 87.5%. SPECT/CT improved SN identification and/or localization compared with planar images in 6 patients (30%). Conclusions. SPECT/CT SN mapping provides additional preoperative data of clinical relevance to SNB in patients with oral cavity SCC.

KW - Hybrid SPECT/CT

KW - Lymphoscintigraphy

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Lymphoscintigraphy for sentinel node mapping using a hybrid single photon emission CT (SPECT)/CT system in oral cavity squamous cell carcinoma

Abstract

Keywords

UN SDGs

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