Lymphoma with recurrent cycles of spontaneous remission and relapse ͟ possible role of apoptosis

Yael Kaufmann; Amira Many; Gideon Rechavi; Orna Mor; Miriam Biniaminov; Esther Rosenthal; Michal Levanon; Jacqueline Davidsohn; Irena Aizman; Ziva Mark; Frida Brok-Simoni; Bracha Ramot

doi:10.1056/NEJM199502233320805

Lymphoma with recurrent cycles of spontaneous remission and relapse ͟ possible role of apoptosis

Yael Kaufmann, Amira Many, Gideon Rechavi, Orna Mor, Miriam Biniaminov, Esther Rosenthal, Michal Levanon, Jacqueline Davidsohn, Irena Aizman, Ziva Mark, Frida Brok-Simoni, Bracha Ramot^*

^*Corresponding author for this work

Hematology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months. During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the…

Original language	English
Pages (from-to)	507-510
Number of pages	4
Journal	New England Journal of Medicine
Volume	332
Issue number	8
DOIs	https://doi.org/10.1056/NEJM199502233320805
State	Published - 23 Feb 1995

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abstract = "We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months. During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the…",

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T1 - Lymphoma with recurrent cycles of spontaneous remission and relapse ͟ possible role of apoptosis

AU - Kaufmann, Yael

AU - Many, Amira

AU - Rechavi, Gideon

AU - Mor, Orna

AU - Biniaminov, Miriam

AU - Rosenthal, Esther

AU - Levanon, Michal

AU - Davidsohn, Jacqueline

AU - Aizman, Irena

AU - Mark, Ziva

AU - Brok-Simoni, Frida

AU - Ramot, Bracha

PY - 1995/2/23

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N2 - We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months. During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the…

AB - We describe a patient with a unique mantle-cell lymphoma, with cycles of acute illness alternating with spontaneous remissions. During the acute phase the patient had fever, generalized lymphadenopathy, hepatosplenomegaly, increased liver-enzyme concentrations, leukocytosis, and thrombocytopenia. These bouts remitted after two to three weeks without treatment. Fifteen such cycles were documented over a period of 50 months. During the acute phase blast-like B lymphocytes in the blood expressed surface IgM, IgD, and CD5, whereas during clinical remission a small population of IgM and CD5+ lymphocytes persisted. Two B-cell clones with differently rearranged heavy-chain genes consistently appeared in the blood during the…

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Lymphoma with recurrent cycles of spontaneous remission and relapse ͟ possible role of apoptosis

Abstract

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