TY - JOUR
T1 - Lymphocytotoxic Autoantibodies Eluted From In Vivo Propagating Sarcoma Cells of Mice
T2 - Brief Communication
AU - Ran, Maya
AU - Yaakubowicz, Margalit
AU - Witz, Isaac P.
N1 - Funding Information:
1 Received August 8,1977; accepted December 16, 1977. 2 Supported by a grant from the United States-Israel Binational Science Foundation and by a grant (4639) from the Israel Academy of Sciences, Israel Commission for Basic Research, Jerusalem, Israel. 3 Department of Microbiology, George S. Wise Center for Life Sciences, Tel-Aviv University, Tel-Aviv, Israel. 4 We thank Mrs. Ora Amitai for excellent technical assistance.
PY - 1978/6
Y1 - 1978/6
N2 - Eluates of SEYF-a cells (from polyoma vlrus-in- duced sarcoma grown In A.BY mice) containing cytotoxic antl- SEYF-a antibodies mediated complement-dependent cytotoxicity of normal lymph node cells. Some lymphocytotoxicity was also mediated by sera of tumor-bearing mice, but the pattern of cytotoxicity was different from that exhibited by tumor eluates. The titer of lymphocytotoxic antibodies in the serum was lower than the titer of anti-SEYF-a antibodies, whereas eluates exhibited similar titers toward both target cells. These results indicated that tumor cells selectively absorbed the lymphocytotoxic antibodies from the serum. Tumor eluates had cytotoxic activity also against thymocytes, splenocytes, and even bone marrow cells. The strain distribution of sensitive thymocytes to the antibodies present in eluates indicated that Thy 1 was not involved. Unfractionated eluates as well as IgG fractions isolated from eluates were active.-J Natl Cancer Inst 60: 1509-1513, 1978.
AB - Eluates of SEYF-a cells (from polyoma vlrus-in- duced sarcoma grown In A.BY mice) containing cytotoxic antl- SEYF-a antibodies mediated complement-dependent cytotoxicity of normal lymph node cells. Some lymphocytotoxicity was also mediated by sera of tumor-bearing mice, but the pattern of cytotoxicity was different from that exhibited by tumor eluates. The titer of lymphocytotoxic antibodies in the serum was lower than the titer of anti-SEYF-a antibodies, whereas eluates exhibited similar titers toward both target cells. These results indicated that tumor cells selectively absorbed the lymphocytotoxic antibodies from the serum. Tumor eluates had cytotoxic activity also against thymocytes, splenocytes, and even bone marrow cells. The strain distribution of sensitive thymocytes to the antibodies present in eluates indicated that Thy 1 was not involved. Unfractionated eluates as well as IgG fractions isolated from eluates were active.-J Natl Cancer Inst 60: 1509-1513, 1978.
UR - http://www.scopus.com/inward/record.url?scp=0018148058&partnerID=8YFLogxK
U2 - 10.1093/jnci/60.6.1509
DO - 10.1093/jnci/60.6.1509
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0018148058
VL - 60
SP - 1509
EP - 1513
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
SN - 0027-8874
IS - 6
ER -
