Lymphocytotoxic Autoantibodies Eluted From In Vivo Propagating Sarcoma Cells of Mice: Brief Communication

Maya Ran, Margalit Yaakubowicz, Isaac P. Witz

Research output: Contribution to journalArticlepeer-review


Eluates of SEYF-a cells (from polyoma vlrus-in- duced sarcoma grown In A.BY mice) containing cytotoxic antl- SEYF-a antibodies mediated complement-dependent cytotoxicity of normal lymph node cells. Some lymphocytotoxicity was also mediated by sera of tumor-bearing mice, but the pattern of cytotoxicity was different from that exhibited by tumor eluates. The titer of lymphocytotoxic antibodies in the serum was lower than the titer of anti-SEYF-a antibodies, whereas eluates exhibited similar titers toward both target cells. These results indicated that tumor cells selectively absorbed the lymphocytotoxic antibodies from the serum. Tumor eluates had cytotoxic activity also against thymocytes, splenocytes, and even bone marrow cells. The strain distribution of sensitive thymocytes to the antibodies present in eluates indicated that Thy 1 was not involved. Unfractionated eluates as well as IgG fractions isolated from eluates were active.-J Natl Cancer Inst 60: 1509-1513, 1978.

Original languageEnglish
Pages (from-to)1509-1513
Number of pages5
JournalJournal of the National Cancer Institute
Issue number6
StatePublished - Jun 1978


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