Lymphocytotoxic antibodies in Israeli patients with rheumatoid arthritis

A. Livneh, A. Renert, O. Avishai, P. Langevitz, E. Gazit

Research output: Contribution to journalArticlepeer-review

Abstract

The presence, antigenic specificity, and clinical role of lymphocytotoxic antibodies (LCAs) were studied in 72 Israeli patients with rheumatoid arthritis (RA). Using the microlymphocytotoxicity assay on a cell panel of 47 donors, LCAs were found in 55% of the 72 RA sera, each displaying a distinct pattern of anti-lymphocytic reactivity, mostly against B lymphocytes. Human lymphocytic antigens (HLA) analysis of donors' lymphocytes suggested that activity of LCA-positive RA sera is HLA directed in 60% of cytotoxic sera. The anti-HLA antibodies found were not autoreactive and were not restricted to a particular class I or class II antigen. Relating the presence of LCAs to selective clinical features revealed that LCAs are inversely associated with the presence of an erosive disease (P < 0.01) and with the patients' HLA-DQw1 (P < 0.01). These findings suggest that LCAs in Israeli patients with RA are very common, multispecific and may have a protective role not mediated through interaction with self-HLA antigens.

Original languageEnglish
Pages (from-to)30-35
Number of pages6
JournalIsrael Journal of Medical Sciences
Volume33
Issue number1
StatePublished - Jan 1997
Externally publishedYes

Keywords

  • Human lymphocytic antigens
  • Lymphocytotoxic antibodies
  • Rheumatoid arthritis

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