Lymphocytes Bearing Surface Ferritin in Patients with Hodgkin's Disease and Breast Cancer

Chaya Moroz, Shamai Giler, Batia Kupfer, Israel Urca, B. Ramot, M. Biniamiov, E. Rosenthal, I. Ben-Bassat, E. Aghai

Research output: Contribution to journalLetterpeer-review

Abstract

To the Editor: In a recent editorial (N Engl J Med 295:1314–1315, 1976) Dr. Siegal reviewed the possible inhibitors of T-cell rosette formation prevalent in serum of patients with Hodgkin's disease. Among others, he mentioned our findings, in which, by enzymic radioiodination of Hodgkin-disease lymphocytes, we demonstrated ferritin on the surface of the cells. The iodinated ferritin was shed into the culture medium after incubation with levamisole, resulting in unmasking of normal surface proteins.1 The possibility was raised that a subpopulation of T cells exists that is specifically sensitive to inhibition of rosette formation by the inhibitor. Indeed, in.

Original languageEnglish
Pages (from-to)1172-1174
Number of pages3
JournalNew England Journal of Medicine
Volume296
Issue number20
DOIs
StatePublished - 19 May 1977
Externally publishedYes

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