@article{7ee84fc1c8874008a18c8c4894c154ec,
title = "LYMPHOCYTE RESPONSE IN SARCOIDOSIS",
abstract = "The response of peripheral lymphocytes of patients with Kveim positive sarcoidosis to a Chase-Siltzbach type-I (spleen J) suspension, normal spleen suspension, and phytoh{\ae}magglutinin (P.H.A.) was assayed in-vitro by 14C-leucine incorporation (nineteen patients), release of migration inhibitory factor (M.I.F.) (seventeen patients), and direct migration inhibition (six patients). No specific response to Kveim suspension in a wide range of doses was detected by these assays. All patients showed diminished responsiveness to P.H.A. when compared with controls. A high spontaneous release in vitro of M.I.F. was found for the lymphocytes of patients with sarcoidosis and could not be augmented by addition of Kveim antigen.",
author = "Marcel Topilsky and Marsha Williams and Siltzbach, \{Louis E.\} and Glade, \{Philip R.\}",
note = "Funding Information: We thank Dr. William Waithe and Dr. Photini Papageorgiou for helpful advice. This research was supported in part by research grant HE-13853-12Al from the National Heart and Lung Institute, research contract NIH 69-2078 within the Special Virus Cancer Program of the National Cancer Institute, and research grant RO1-All-0422 from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, U.S. Public Health Service. P. R. G. is a recipient of a research career development award (Al-46371) of the U.S. Public Health Service.",
year = "1972",
month = jan,
day = "15",
doi = "10.1016/S0140-6736(72)90680-0",
language = "אנגלית",
volume = "299",
pages = "117--120",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier B.V.",
number = "7742",
}