@article{eae2f2f31e3e45ffb53d535fa44fe02b,
title = "Lymph node density in oral cavity cancer: Results of the International Consortium for Outcomes Research",
abstract = "Background:Lymph node density (LND) has previously been reported to reliably predict recurrence risk and survival in oral cavity squamous cell carcinoma (OSCC). This multicenter international study was designed to validate the concept of LND in OSCC.Methods:The study included 4254 patients diagnosed as having OSCC. The median follow-up was 41 months. Five-year overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), locoregional control and distant metastasis rates were calculated using the Kaplan-Meier method. Lymph node density (number of positive lymph nodes/total number of excised lymph nodes) was subjected to multivariate analysis.Results:The OS was 49% for patients with LND≤0.07 compared with 35% for patients with LND>0.07 (P<0.001). Similarly, the DSS was 60% for patients with LND≤0.07 compared with 41% for those with LND>0.07 (P<0.001). Lymph node density reliably stratified patients according to their risk of failure within the individual N subgroups (P=0.03). A modified TNM staging system based on LND ratio was consistently superior to the traditional system in estimating survival measures.Conclusion:This multi-institutional study validates the reliability and applicability of LND as a predictor of outcomes in OSCC. Lymph node density can potentially assist in identifying patients with poor outcomes and therefore for whom more aggressive adjuvant treatment is needed.",
keywords = "lymph node density, oral cavity, squamous, survival",
author = "Patel, {S. G.} and M. Amit and Yen, {T. C.} and Liao, {C. T.} and P. Chaturvedi and Agarwal, {J. P.} and Kowalski, {L. P.} and A. Ebrahimi and Clark, {J. R.} and Cernea, {C. R.} and Brandao, {S. J.} and M. Kreppel and J. Z{\"o}ller and D. Fliss and E. Fridman and G. Bachar and T. Shpitzer and Bolzoni, {V. A.} and Patel, {P. R.} and S. Jonnalagadda and Robbins, {K. T.} and Shah, {J. P.} and Z. Gil",
note = "Funding Information: Esther Eshkol is thanked for her editorial assistance. We would like to thank Dr Ester Shabtai and Carmit Rubin (MA), Statistics Services Unit, Tel Aviv, Israel, for the statistical analysis. This research was supported by the Israel Science Foundation, the Israel Cancer Association (grant donated by Ellen and Emanuel Kronitz in memory of Dr Leon Kronitz No. 20090068), the Israeli Ministry of Health (No. 3-7355), the Weizmann Institute – TASMC Joint Grant, the ICRF Barbara S Goodman endowed research career development award (2011-601-BGPC), an Intramural grant from Rambam Medical Center and a grant from the US-Israel Binational Science Foundation.",
year = "2013",
month = oct,
day = "15",
doi = "10.1038/bjc.2013.570",
language = "אנגלית",
volume = "109",
pages = "2087--2095",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "8",
}
