TY - JOUR
T1 - Lyme neuroborreliosis
T2 - infection, immunity, and inflammation
AU - Pachner, Andrew R.
AU - Steiner, Israel
PY - 2007/6
Y1 - 2007/6
N2 - Lyme neuroborreliosis (LNB), the neurological manifestation of systemic infection with the complex spirochaete Borrelia burgdorferi, can pose a challenge for practising neurologists. This Review is a summary of clinical presentation, diagnosis, and therapy, as well as of recent advances in our understanding of LNB. Many new insights have been gained through work in experimental models of the disease. An appreciation of the genetic heterogeneity of the causative pathogen has helped clinicians in their understanding of the diverse presentations of LNB.
AB - Lyme neuroborreliosis (LNB), the neurological manifestation of systemic infection with the complex spirochaete Borrelia burgdorferi, can pose a challenge for practising neurologists. This Review is a summary of clinical presentation, diagnosis, and therapy, as well as of recent advances in our understanding of LNB. Many new insights have been gained through work in experimental models of the disease. An appreciation of the genetic heterogeneity of the causative pathogen has helped clinicians in their understanding of the diverse presentations of LNB.
UR - http://www.scopus.com/inward/record.url?scp=34248371612&partnerID=8YFLogxK
U2 - 10.1016/S1474-4422(07)70128-X
DO - 10.1016/S1474-4422(07)70128-X
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C2 - 17509489
AN - SCOPUS:34248371612
SN - 1474-4422
VL - 6
SP - 544
EP - 552
JO - The Lancet Neurology
JF - The Lancet Neurology
IS - 6
ER -