Lupus erythematosus tumidus induced by sex reassignment surgery

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We describe a case of sex reassignment surgery and the subsequent development of lupus erythematosus tumidus (LET). LET is characterized clinically by erythematous, succulent, edematous, nonscarring plaques in sun-exposed areas. Results of histological examination show perivascular and periadnexal lymphocytic infiltration and interstitial mucin deposition. This report emphasizes that environmental triggers, including prolonged exposure to significant doses of estrogens as part of sex reassignment surgery, may lead to the development of lupus in a nonpredisposed individual.

Original languageEnglish
Pages (from-to)1938-1940
Number of pages3
JournalJournal of Rheumatology
Issue number9
StatePublished - Sep 2007


  • Estrogen
  • Lupus erythematosus tumidus
  • Sex reassignment surgery
  • Silicone augmentation mammoplasty
  • Systemic lupus erythematosus


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