Lupus anticoagulant: Significance in habitual first-trimester abortion

H. J.A. Carp*, Y. Menashe, Y. Frenkel, A. Many, L. Nebel, V. Toder, S. Mashiach

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Therapy with steroids and aspirin has been reported to benefit pregnancies in patients with lupus anticoagulant (LA). In this study, habitual first- trimester aborters with LA using steroids and aspirin were compared to a control group of untreated habitual aborters without LA. In habitual aborters with LA, 12 of 24 (50%) pregnancies reached the second trimester as compared to 8 of 22 pregnancies (36%) in the control group. Since the treated group did no better than the control group, LA probably is not a cause of first- trimester abortion. However, once the second trimester is reached, a 50% incidence of growth retardation was found, and 42% of fetuses died in the second or third trimester in treated LA patients. Treatment with steroids and anti-platelet aggregating agents may be necessary despite the attendant risks to prevent those sequelae in the second and third trimesters. There was a 29% live birth rate in treated LA patients; the rate was 36% in control patients. However, this rate was produced only by early intervention, which was unnecessary in the control patients.

Original languageEnglish
Pages (from-to)549-552
Number of pages4
JournalThe Journal of reproductive medicine
Issue number7
StatePublished - 1993
Externally publishedYes


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