Lupus anticoagulant: Correlation with magnetic resonance imaging of brain lesions

Y. Molad, Y. Sidi, M. Gornish, M. Lerner, J. Pinkhas, A. Weinberger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

56 Scopus citations


Brain magnetic resonance imaging (MRI) was performed in 21 patients with systemic lupus erythematosus (SLE) with and without lupus anticoagulant (LAC), one lupus-like patient and 5 patients with primary antiphospholipid antibody syndrome. Thirteen patients had white matter focal brain lesions on MRI, 10 of whom had LAC (p = 0.03). We found no correlation between these lesions and neurologic manifestations, nor any clinical or serologic indices of activity of SLE. Our MRI lesions were similar to those described in multiple sclerosis and may indicate a similar pathologic process.

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalJournal of Rheumatology
Issue number4
StatePublished - 1992
Externally publishedYes


  • MRI
  • lupus anticoagulant
  • neuropsychiatric SLE


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