Lung transplantation in patients with cystic fibrosis: The Israeli experience

Dario Prais, Yael Raviv, David Shitrit, Alon Yellin, Gideon Sahar, Danielle Bendayan, Yaacov Yahav, Ori Efrati, Nira Reichart, Hannah Blau, Ilana Bakal, Gila Buchman, Milton Saute, Bernardo Vidne, Mordechai R. Kramer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Background: Lung transplantation is a well-established therapeutic option for end-stage lung disease in cystic fibrosis. Although it confers a clear survival advantage, outcome differs among centers according to local experience, patient selection, transplantation procedure, and postoperative care. Objectives: To evaluate the national Israeli experience with lung transplantation in patients with CF. Methods: We reviewed the medical charts of all CF patients who underwent lung transplantation between January 1996 and June 2005 at the two Israeli centers that perform this procedure. Results: Eighteen tran splantations were performed in 17 patients. Mean patient age at transplantation was 25.3 ± 9.1 years, and mean duration of follow-up in survivors (n=14) was 37.2 months (range 1-113 months). The actuarial survival rate was 88% at 1 year and 74% at 5 years. Pulmonary function, expressed as percent of predicted normal forced expiratory volume in 1 sec, improved from 22.4 ± 8.1% to 76 ± 16.8% at one year after transplantation. Bronchiolitis obliterans syndrome was diagnosed in 5 patients (29%), of whom 2 died and 2 are currently candidates for retransplantation. Median time to onset of BOS was 34.2 months (range 17-64 months). Conclusion: In Israel, the early and inter mediate-term results of lung transplantation for cystic fibrosis are encouraging. BOS remains a major complication that threatens long-term outcome.

Original languageEnglish
Pages (from-to)396-399
Number of pages4
JournalIsrael Medical Association Journal
Volume8
Issue number6
StatePublished - Jun 2006

Keywords

  • Cystic fibrosis
  • Lung transplantation
  • Pulmonary outcome

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