Lung function and cardiopulmonary exercise capacity in patients with corrected tetralogy of Fallot

Gabriel Izbicki, Gershon Fink, Avi Algom, Rafael Hirsch, Leonard Blieden, Eliezer Klainman, Elie Picard, Shmuel Goldberg, Mordechai R. Kramer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: Since surgical repair of tetralogy of Fallot was introduced, follow-up studies have shown that the majority of patients lead active lives and have no subjective exercise limitation. Objectives: To examine lung function, cardiopulmonary functional capacity and echo-Doppler assessment of pulmonary pressure in adult patients 20 years after repair of TOF. Methods: Unselected consecutive patients performed full lung function testing, progressive cardiopulmonary exercise, and echo-Doppler assessments of pulmonary pressure. Results: Fifty consecutive patients (33 men, 17 women) aged 29 ± 11 years who underwent surgical repair of TOF at age 10.1 ± 10.9 years were enrolled. Patients after TOF showed no restriction (forced expiratory vital capacity 80%, total lung capacity 91%) and had normal oxygen saturation (97%) and 6 minute walking distance (600 meters). Echocardiography showed normal pulmonary pressure and left ventricular ejection function (62%). Cardiopulmonary exercise testing showed mild limitation of exercise capacity with oxygen uptake at maximal effort of 75-78% predicted. Conclusions: After corrections of TOF the study patients had normal lung function and pulmonary arterial pressure but mild limitation in their exercise capacity.

Original languageEnglish
Pages (from-to)564-567
Number of pages4
JournalIsrael Medical Association Journal
Issue number9
StatePublished - Aug 2008
Externally publishedYes


  • Echocardiography
  • Fallot
  • Follow-up
  • Pulmonary artery pressure
  • Pulmonary function test


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