Lower Urinary Tract Symptoms and Benign Prostate Hyperplasia Features Among Male BRCA Mutation Carriers

Hanan Goldberg*, Liat Shavit Grievink, Roy Mano, Yaara Ber, Rachely Ozalbo, Sivan Tuval, Jack Baniel, David Margel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective To analyze lower urinary tract symptoms and benign prostate hyperplasia features among male BRCA1 and 2 carriers and an age-matched control group. Methods Male BRCA carriers and noncarriers aged 40-70 years were enrolled in our cross-sectional study. Relevant clinical data were collected, and patients filled the International Prostate Symptom Score. Patients also underwent prostate-specific antigen (PSA) blood testing, digital rectal examination, uroflowmetry, and post-void residual ultrasound examination. As part of their routine follow-up, BRCA carriers underwent prostate magnetic resonance imaging. Results Overall, 87 carriers and 30 noncarriers were enrolled. The median age, mean body mass index, and comorbidities in both groups were similar. Maximal flow (QMAX) was higher in the noncarrier group (16.9 mL/s vs 12 mL/s, P =.01). Mean prostate volume among all BRCA carriers was 38.8 cc (19.7), but BRCA1 patients had larger glands with higher mean PSA and PSA density than BRCA2 patients (41.8 cc vs 33.1 cc, P =.047, 1.84 ng/mL vs 1.07 ng/mL, P =.006, and.044 vs.032, P =.042, respectively). Multivariate analysis demonstrated age being the sole significant predictor of PSA density in BRCA2 patients. Conclusion Male carrying BRCA mutations have significantly lower QMAX than healthy men. BRCA1 patients have on average larger prostate glands and higher PSA than BRCA2 patients. Further research is required to decipher the association of lower urinary tract symptoms or benign prostate hyperplasia with BRCA carriers.

Original languageEnglish
Pages (from-to)71-75
Number of pages5
StatePublished - Oct 2017


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