Lower cognitive performance in healthy G2019S LRRK2 mutation carriers

Avner Thaler, Anat Mirelman, Tanya Gurevich, Ely Simon, Avi Orr-Urtreger, Karen Marder, Susan Bressman, Nir Giladi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: To assess cognitive abilities of healthy first-degree relatives of Ashkenazi patients with Parkinson disease (PD), carriers of the G2019S mutation in the LRRK2 gene. Methods: In this observational study, 60 consecutive healthy first-degree relatives (aged 50.9 ± 6.2 years; 48% male; 30 G2019S carriers) were assessed using a computerized cognitive program, the Montreal Cognitive Assessment questionnaire, the Unified Parkinson's Disease Rating Scale Part III, and the Geriatric Depression Scale. Results: G2019S carriers scored significantly lower on the computerized executive function index (p = 0.04) and on specific executive function tasks (Stroop test, p = 0.007). Conclusion: Carrying the LRRK2 G2019S mutation was associated with lower executive performance in a population at risk for PD.

Original languageEnglish
Pages (from-to)1027-1032
Number of pages6
Issue number10
StatePublished - 4 Sep 2012


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