Low plasma vitamin D levels and muscle-related adverse effects in statin users

Alon Eisen, Eli Lev, Zaza Iakobishvilli, Avital Porter, David Brosh, David Hasdai, Aviv Mager

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Treatment with HMG-CoA reductase inhibitors (statins) is often complicated by muscle-related adverse effects (MAEs). Studies of the association between low plasma vitamin D levels and MAEs have yielded conficting results. Objectives: To determine if low plasma vitamin D level is a risk factor for MAEs in statin users. methods: Plasma levels of 25(OH) vitamin D were measured as part of the routine evaluation of unselected statin-treated patients attending the coronary and lipid clinics at our hospital during the period 2007-2010. Medical data on muscle complaints and statin use were retrieved from the medical files. Creatine kinase (CK) levels were derived from the hospital laboratory database. results: The sample included 272 patients (141 men) aged 33- 89 years. Mean vitamin D level was 48.04 nmol/L. Levels were higher in men (51.0 ± 20.5 vs. 44.7 ± 18.9 nmol/L, P = 0.001) and were unaffected by age. MAEs were observed in 106 patients (39%): myalgia in 95 (35%) and CK elevation in 20 (7%); 9 patients (3%) had both. There was no difference in plasma vitamin D levels between patients with and without myalgia (46.3 ± 17.7 vs. 48.9 ± 21.0 nmol/L, P = 0.31), with and without CK elevation (50.2 ± 14.6 vs. 47.8 ± 20.3 nmol/L, P = 0.60), or with or without any MAE (50.4 ± 15.0 vs. 47.8 ± 10.2 nmol/L, P = 0.27). These fndings were consistent when analyzed by patient gender and presence/absence of coronary artery disease, and when using a lower vitamin D cutoff (< 25 nmol/L). conclusions: There is apparently no relationship between plasma vitamin D level and risk of MAEs in statin users.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalIsrael Medical Association Journal
Volume16
Issue number1
StatePublished - Jan 2014
Externally publishedYes

Keywords

  • Creatine phosphokinase
  • HMG Co-A reductase inhibitor
  • Muscle-related adverse effect (MAE)
  • Myalgia
  • Myopathy
  • Statin
  • Vitamin D

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