TY - JOUR
T1 - Low-level visible light (LLVL) irradiation promotes proliferation of mesenchymal stem cells
AU - Lipovsky, Anat
AU - Oron, Uri
AU - Gedanken, Aharon
AU - Lubart, Rachel
PY - 2013/7
Y1 - 2013/7
N2 - Low-level visible light irradiation was found to stimulate proliferation potential of various types of cells in vitro. Stem cells in general are of significance for implantation in regenerative medicine. The aim of the present study was to investigate the effect of low-level light irradiation on the proliferation of mesenchymal stem cells (MSCs). MSCs were isolated from the bone marrow, and light irradiation was applied at energy densities of 2.4, 4.8, and 7.2 J/cm2. Illumination of the MSCs resulted in almost twofold increase in cell number as compared to controls. Elevated reactive oxygen species and nitric oxide production was also observed in MSCs cultures following illumination with broadband visible light. The present study clearly demonstrates the ability of broadband visible light illumination to promote proliferation of MSCs in vitro. These results may have an important impact on wound healing.
AB - Low-level visible light irradiation was found to stimulate proliferation potential of various types of cells in vitro. Stem cells in general are of significance for implantation in regenerative medicine. The aim of the present study was to investigate the effect of low-level light irradiation on the proliferation of mesenchymal stem cells (MSCs). MSCs were isolated from the bone marrow, and light irradiation was applied at energy densities of 2.4, 4.8, and 7.2 J/cm2. Illumination of the MSCs resulted in almost twofold increase in cell number as compared to controls. Elevated reactive oxygen species and nitric oxide production was also observed in MSCs cultures following illumination with broadband visible light. The present study clearly demonstrates the ability of broadband visible light illumination to promote proliferation of MSCs in vitro. These results may have an important impact on wound healing.
KW - Mesenchymal stem cells
KW - Proliferation
KW - Visible light
UR - http://www.scopus.com/inward/record.url?scp=84879838382&partnerID=8YFLogxK
U2 - 10.1007/s10103-012-1207-z
DO - 10.1007/s10103-012-1207-z
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AN - SCOPUS:84879838382
SN - 0268-8921
VL - 28
SP - 1113
EP - 1117
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 4
ER -