Low frequencies of autoimmunity-associated PTPN22 polymorphisms in MODY patients, including those transiently expressing islet cell autoantibodies

Petr Heneberg, Milena Malá, Tohru Yorifuji, Galia Gat-Yablonski, Yael Lebenthal, Toshihiro Tajima, Viviane Nogaroto, Blanka Rypáčková, Lucie Kocková, Jana Urbanová, Michal Anděl

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene encodes lymphoid tyrosine phosphatase (LYP), which is expressed primarily in lymphoid tissues. The functional but geographically highly variable PTPN22 single-nucleotide polymorphisms (SNPs), particularly c.1858C>T, contribute to the onset and progression of autoimmunity-associated diseases and facilitate the expression of disease-associated autoantibodies. In Central Europe, 17-25% of patients with monogenic diabetes (maturity-onset diabetes of the young, MODY) transiently express islet cell autoantibodies. Methods: We addressed the links between the functional and geographically variable PTPN22 SNPs with MODY manifestation and the expression of islet cell autoantibodies in 276 MODY patients who originated from four regions (the Czech Republic, Israel, Japan and Brazil). Results: The frequency of PTPN22 polymorphisms in the MODY patients was similar to those in geographically matched healthy populations, with the exception of c.788G>A, the minor allele frequency of which was significantly elevated in the Czech hepatocyte nuclear factor 1-α (HNF1A) MODY patients [odds ratio (OR) 4.8, 95% confidence interval (CI) 2.2-10.7] and the Brazilian MODY patients (OR 8.4, 95% CI 1.8-39.1). A barely significant increase in the c.788G>A minor allele was also detected in the islet cell autoantibody-positive Czech MODY patients. However, c.788A behaves as a loss-of-function mutant in T cells, and thus protects against autoimmunity. Conclusions: MODY patients (including islet cell autoantibody-positive cases) do not display any increase in autoimmunity-associated PTPN22 alleles. The absence of autoimmunity-associated PTPN22 alleles was also demonstrated in latent autoimmune diabetes in adults, which suggests that the slow kinetics of the onset of autoantibodies is subject to a regulation that is different from that experienced in type 1 diabetes and other autoimmune disorders.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalInternational Archives of Allergy and Immunology
Volume166
Issue number3
DOIs
StatePublished - 28 May 2015
Externally publishedYes

Funding

FundersFunder number
Japan Society for the Promotion of Science15K09636

    Keywords

    • Atypical diabetes
    • Autoimmunity
    • ICA512
    • Lymphoid tyrosine phosphatase
    • Maturity-onset diabetes of the young
    • Monogenic diabetes
    • PTPN22 gene
    • PTPRN

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