TY - JOUR
T1 - Low energy laser irradiation
T2 - Laser-Tissue Interaction VI 1995
AU - Schwartz, Michal
AU - Yoles, Eti
AU - Solomon, Arieh
AU - Katz, Chaya
AU - Hai, Inbal
AU - Belkin, Michael
N1 - Publisher Copyright:
© 1995 SPIE. All rights reserved.
PY - 1995/5/22
Y1 - 1995/5/22
N2 - We have tested the effects of early posttraumatic low-energy laser irradiation on injured neural tissues. Rat optic nerves were crushed by a calibrated forceps and the ensuing degenerative processes were followed up electrophysiologically and by on-line metabolism measurements, using nicotinamide adenine dinucleotide autofluorescence in response to anoxia. The irradiation not only decelerated the posttraumatic degenerative processes but also increased axonal survival as shown by visual evoked potential response recording. The irradiation also reduced significantly the very early posttraumatic reduction in the metabolic activity of the optic nerve. It seems that the low-energy irradiation, possibly by a photochemical mechanism and by modifying the cellular metabolism, prevents the spread of the injury effects from the injury site and along the axons. This action of low-energy laser irradiation is akin to the neuroprotective effects ascribed to various drugs, such as corticosteroids.
AB - We have tested the effects of early posttraumatic low-energy laser irradiation on injured neural tissues. Rat optic nerves were crushed by a calibrated forceps and the ensuing degenerative processes were followed up electrophysiologically and by on-line metabolism measurements, using nicotinamide adenine dinucleotide autofluorescence in response to anoxia. The irradiation not only decelerated the posttraumatic degenerative processes but also increased axonal survival as shown by visual evoked potential response recording. The irradiation also reduced significantly the very early posttraumatic reduction in the metabolic activity of the optic nerve. It seems that the low-energy irradiation, possibly by a photochemical mechanism and by modifying the cellular metabolism, prevents the spread of the injury effects from the injury site and along the axons. This action of low-energy laser irradiation is akin to the neuroprotective effects ascribed to various drugs, such as corticosteroids.
UR - http://www.scopus.com/inward/record.url?scp=58149232215&partnerID=8YFLogxK
U2 - 10.1117/12.209932
DO - 10.1117/12.209932
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AN - SCOPUS:58149232215
SN - 0277-786X
VL - 2391
SP - 627
EP - 633
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
Y2 - 1 February 1995 through 8 February 1995
ER -